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Scientists are concerned about BPA's behavioral effects on fetuses, infants, and children at current exposure levels because it can affect the prostate gland, mammary gland, and lead to early puberty in girls. Testicular size reaches maximal adult size about 6 years after the onset of puberty. The signal and mechanism releasing the arcuate nucleus from inhibition have been the subject of investigation for decades and remain incompletely understood. Those that involve chronic inflammation or interfere with nutrition have the strongest effect. The endocrine reproductive system becomes functional by the end of the first trimester of fetal life. The most important of the environmental influences is clearly nutrition, but a number of others have been identified, all which affect timing of female puberty and menarche more clearly than male puberty.

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