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National Center for Biotechnology Information , U. Scientific studies mainly have been reported to occur that chronic effects like bile and gastric fluid gastroesophageal reflux, cause esophageal melanosis [ 2 , 5 , 12 ]. Esophageal melanosis, reflux esophagitis, and chronic pangastritis were diagnosed histopathologically Fig. Tobacco use leads to chronic damage to upper gastrointestinal mucosa. Complaints dropped with anti-acid therapy and case was followed by intermittent endoscopic procedures because of precursor melanocytic lesions. The endoscopic examination in this case found has a reflux esophagitis in phase with Los Angeles phase B and chronic esophagitis was found on pathologic examination. Likewise melanosis process, upper gastrointestinal antioxidant defense is thought to function as barriers [ 7 ].

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