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However, this finding may be an underestimate because affected individuals do not always tell their family members that they have the condition, and hidradenitis suppurativa is sometimes misdiagnosed as other skin disorders. The blocked hair follicles trap bacteria, leading to inflammation and rupture. Autosomal dominant inheritance means one copy of an altered gene in each cell is sufficient to cause the disorder. In some cases, nodules appear in other areas, such as the nape of the neck, waist, and inner thighs. This complex cuts apart cleaves many different proteins, which is an important step in several chemical signaling pathways. Hidradenitis suppurativa was once thought to be a rare condition because only the most severe cases were reported. The nodules become inflamed and painful.

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