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Health Matters : In your practice do you see a lot of this adrenal gland problems, or is it rare? It makes up a fairly small percentage of my practice. Tamber : There are a bunch of different things that can cause adrenal problems and cause adrenal insufficiency. The research about cortisol replacement in Addison's disease mainly focuses on the type of steroid that we are giving as a replacement therapy, because right now we actually don't have the perfect treatment for Addison's disease or adrenal insufficiency from any cause. It's that the pituitary gland in the brain, which controls the adrenal glands, is not sending out the proper signal to the adrenals to do what they need to do. The problem is that in a normal person whose adrenal glands are working perfectly, the cortisol levels actually reach their peak very early in the morning. The cortisol levels start to rise, they tell the liver to start releasing sugar into the bloodstream so the rest of the body can start using that sugar to do what it needs to do, and the cortisol levels will be up at those early morning hours.

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